Fabrication of  Macro- AND Micropore Forming DCPD/ β-TCP Porous Scaffolds: Effect of Setting-Time Reaction and Acidic Calcium Phosphate Solution

Mohammed, Ahmed Hafedh Mohammed; bin Shariff, Khairul Anuar; Abu Bakar, Mohamad Hafizi

doi:10.22068/ijmse.3402

Volume 20, Issue 4 (December 2023) IJMSE 2023, 20(4): 1-10 | Back to browse issues page

‎ 10.22068/ijmse.3402

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Mohammed A H M, bin Shariff K A, Abu Bakar M H. Fabrication of Macro- AND Micropore Forming DCPD/ β-TCP Porous Scaffolds: Effect of Setting-Time Reaction and Acidic Calcium Phosphate Solution. IJMSE 2023; 20 (4) :1-10
URL: http://ijmse.iust.ac.ir/article-1-3402-en.html

Fabrication of Macro- AND Micropore Forming DCPD/ β-TCP Porous Scaffolds: Effect of Setting-Time Reaction and Acidic Calcium Phosphate Solution

Ahmed Hafedh Mohammed Mohammed

, Khairul Anuar Bin Shariff

, Mohamad Hafizi Abu Bakar

Abstract: (7446 Views)

The coated β-tricalcium phosphate (β-TCP) with dicalcium phosphate dihydrate (DCPD) has attracted much attention in the biomaterials field due to the increase in its osteoconductivity. Besides, the porous bioceramic scaffolds with controlled pore sizes are significant in stimulating bone-like cell activity. In this study, the effect of the setting-time process and acidic-calcium phosphate (CaP) concentrations on the fabrication and properties of porous DCPD/ β-TCP scaffolds were studied. Subsequently, the specimens were examined using X-ray diffraction (XRD), scanning electron microscopy (SEM), compression strength and Fourier transforms infrared (FTIR). The study results revealed that the porous DCPD/ β-TCP scaffolds with macro- and micropore sizes were successfully obtained after the 300-600 µm of porous β-TCP granules were exposed to an acidic-CaP solution. Furthermore, the setting-time process and acidic-CaP concentrations increased the DCPD interlocking between granules, and the mechanical strengths of scaffolds increased up to 0.5 MPa. Meanwhile, the porosity levels were changed based on the formation of DCPD crystals. This study was expected to provide novel insights to researchers in the field of bioceramics through its investigation on the creation of porous DCPD/ β-TCP scaffolds.

Keywords: Bioceramic, ceramic coating, calcium phosphate, bone remodelling, porous β-TCP scaffolds.